New Scenarios in Pharmacological Treatments of Head and Neck Squamous Cell Carcinomas
Cristina Porcheri, Thimios A. Mitsiadis
Abstract
Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent types of cancer with a lethal outcome in half of the diagnosed cases. Mostly, HNSCC develops in the oral cavity, and its development is associated with tobacco and areca nut/betel quid usage, alcohol consumption, and HPV infection. Oral squamous cell carcinoma, as other head and neck cancers, presents a high degree of intratumor heterogeneity, which makes their treatment difficult, and directly correlates with drug resistance. Since the classical treatments for HNSCC oftentimes do not resolve the clinical picture, there is great need for novel therapeutic approaches, models for drug testing, and new drug delivery systems.
Topics & Concepts
Head and neck squamous-cell carcinomaMedicineHead and neck cancerArecaBasal cellOncologySquamous cell cancerHead and neckBetelCancerInternal medicineCancer researchSurgeryNutStructural engineeringEngineeringRNA Interference and Gene DeliveryHead and Neck Cancer StudiesCancer-related Molecular Pathways