Role of the polycystins as mechanosensors of extracellular stiffness
Elisa Agnese Nigro, Alessandra Boletta
Abstract
Polycystin-1 has recently emerged as a possible receptor able to sense extracellular stiffness and to negatively control the cellular actomyosin contraction machinery. Here, we revisit a large body of literature on autosomal dominant polycystic kidney disease providing a new possible mechanistic view on the topic.
Topics & Concepts
ExtracellularCell biologyAutosomal dominant polycystic kidney diseaseContraction (grammar)Polycystic kidney diseaseBiologyEndocrinologyKidneyGenetic and Kidney Cyst DiseasesBiomedical Research and PathophysiologyMicrotubule and mitosis dynamics