Psoriasis treatment using minimally manipulated umbilical cord-derived mesenchymal stem cells: A case report
Hyunjun Ahn, Sang Yeon Lee, Won‐Ju Jung, Jia Pi, Kye-Ho Lee
Abstract
BACKGROUND: Psoriasis is a chronic autoimmune disease that usually manifests as a red scaly epidermis, induration, and hyperproliferation of basal keratinocytes. About 2% of the world's population suffers from psoriasis but there are no clear therapeutics yet. Recently, mesenchymal stem cells (MSCs) have been regarded as a therapeutic alternative for autoimmune diseases, as they possess immunosuppressive effects without risks. Human umbilical cord-derived MSCs effectively regulate immune cells and are characterized by low immunogenicity, which has many advantages in treating immune diseases. CASE SUMMARY: round, all erythema completely disappeared, and the psoriasis did not recur. CONCLUSION: Minimally manipulated umbilical cord-derived MSC transplantation can potentially treat patients who suffer from psoriasis.