Thermosensitive biomaterial gels with chemical permeation enhancers for enhanced microneedle delivery of naltrexone for managing opioid and alcohol dependency
Kevin V. Tobin, Nicole K. Brogden
Abstract
formulations with benzyl alcohol alone. This formulation would require a smaller size patch than previously used to deliver NTX in humans, with half the NTX concentration. This is the first time poloxamer biomaterials have been used in combination with CPEs to improve MN-assisted transdermal delivery of an opioid antagonist. Here we have demonstrated that P407 in combination with CPEs effectively sustains NTX delivery in MN-treated skin while requiring less NTX than previously needed to meet clinical goals.
Topics & Concepts
TransdermalNaltrexonePoloxamer 407PermeationChemistryDrug deliveryPolyvinyl alcoholPoloxamerPharmacologyBiomedical engineeringOpioidCopolymerMedicineOrganic chemistryBiochemistryReceptorPolymerMembraneAdvancements in Transdermal Drug DeliveryAdvanced Drug Delivery SystemsOcular Surface and Contact Lens