Discovery of novel oxazole-based macrocycles as anti-coronaviral agents targeting SARS-CoV-2 main protease
Lamya H. Al-Wahaibi, Ahmed Mostafa, Yaser A. Mostafa, Ola F. Abou‐Ghadir, Ahmed H. Abdelazeem, Ahmed M. Gouda, Omnia Kutkat, Noura M. Abo Shama, Mahmoud Shehata, Hesham A. M. Gomaa, Mostafa Abdelrahman, Fatma A. Mohamed, Xuyuan Gu, Mohamed A. Ali, Laurent Trembleau, Bahaa G. M. Youssif
Topics & Concepts
ChemistryVero cellCytotoxicityIC50IsopropylDocking (animal)StereochemistryEnzymeMTT assayLead compoundPotencyOxazoleProteaseIn vitroStructure–activity relationshipBiochemistryOrganic chemistryMedicineNursingComputational Drug Discovery MethodsSynthesis and biological activityCancer therapeutics and mechanisms