Replacement of S14 Protein in Ribosomes of Zinc-Starved Mycobacteria Reduces Spectinamide Sensitivity
Yunlong Li, Ravi Kiran Koripella, Manjuli R. Sharma, Richard Lee, Rajendra K. Agrawal, Anil K. Ojha
Abstract
Zinc is an essential micronutrient for mycobacteria, and its depletion induces multiple adaptive changes in cellular physiology, the most remarkable of which are remodeling and hibernation of ribosomes. Ribosome remodeling, induced upon relatively moderate depletion of zinc, involves replacement of multiple ribosomal proteins containing the zinc-binding CXXC motif (called C+ r proteins) by their motif-free C− paralogs.
Topics & Concepts
RibosomeZincRibosomal proteinBiologyRibosomal RNAMicronutrientBiochemistryProtein biosynthesisCytosolRibosome profilingCell biologyChemistryRNAGeneEnzymeOrganic chemistryRNA and protein synthesis mechanismsRNA modifications and cancerBacterial Genetics and Biotechnology