Peroxisomal Fatty Acid Oxidation and Glycolysis Are Triggered in Mouse Models of Lesional Atopic Dermatitis
Petra Pavel, Géraldine Leman, Martin Hermann, Christian Ploner, Thomas O. Eichmann, Deborah Minzaghi, Franz P.W. Radner, Barbara Del Frari, Robert Gruber, Sandrine Dubrac
Abstract
mouse epidermis is essential for keratinocyte proliferation and adenosine triphosphate synthesis but does not contribute to local inflammation. Thus, this work evidenced a metabolic shift toward enhanced peroxisomal β-oxidation and anaerobic glycolysis in ADL epidermis.
Topics & Concepts
Atopic dermatitisPeroxisomeGlycolysisBeta oxidationDermatologyChemistryBiochemistryFatty acidMedicineMetabolismGeneDermatology and Skin DiseasesExercise and Physiological ResponsesPharmacological Effects of Natural Compounds