Liver MRI–derived Proton Density Fat Fraction Predicts Diabetes Risk in Patients with Obesity: A Dose-Response Study
Ming Deng, Zhen Li, Li Sun, Huawei Wang, Jun Tang, Y. Liu, Xunuo Chen, Haibo Xu, Zhe Dai
Abstract
The liver MRI–derived proton density fat fraction (PDFF) independently predicted prediabetes and diabetes risk in patients with obesity, and the liver PDFF–dysglycemia relationship was partially mediated by liver enzymes.
Topics & Concepts
PrediabetesMedicineInternal medicineType 2 diabetesOdds ratioDiabetes mellitusSteatosisGastroenterologyEndocrinologyImpaired fasting glucoseObesityFatty liverImpaired glucose toleranceMetforminHepatologyLiver diseaseAlanine transaminaseRetrospective cohort studyGlucose tolerance testRisk factorNonalcoholic fatty liver diseaseMetabolic syndromeLogistic regressionType 1 diabetesLiver Disease Diagnosis and TreatmentDiet and metabolism studiesMetabolomics and Mass Spectrometry Studies