Structural basis of γ-secretase inhibition and modulation by small molecule drugs
Guanghui Yang, Rui Zhou, Xuefei Guo, Chuangye Yan, Jianlin Lei, Yigong Shi
Topics & Concepts
PresenilinBiologyAllosteric regulationAmyloid precursor protein secretaseExtracellularCell biologySmall moleculeDrug discoveryBinding siteBiochemistryAmyloid precursor proteinNeuroscienceBiophysicsAlzheimer's diseaseEnzymeDiseaseInternal medicineMedicineAlzheimer's disease research and treatmentsComputational Drug Discovery MethodsProtein Structure and Dynamics