Genetically encoding ε-<i>N</i>-benzoyllysine in proteins
Yan‐Li Ji, Conghui Ren, Hui Miao, Zhili Pang, R. Xiao, Xiaochen Yang, Weimin Xuan
Abstract
Lysine ε-N-benzoylation is a recently identified PTM occurring on histone proteins, and herein we genetically encoded ε-N-benzoyl-lysine (BzK) into recombinant proteins in E. coli and mammalian cells, and applied it for the modification of histone proteins and the analysis of sirtuin debenzoylase activity.
Topics & Concepts
Encoding (memory)LysineComputational biologyGenetically engineeredChemistryGeneticsBiologyGeneAmino acidNeuroscienceSirtuins and Resveratrol in MedicineRNA and protein synthesis mechanismsUbiquitin and proteasome pathways