Patient-Reported Symptom Severity in a Nationwide Myasthenia Gravis Cohort
Malin Petersson, Amalia Feresiadou, Daniel Jons, Andreea Ilinca, Fredrik Lundin, Rune Johansson, Anna Budzianowska, Anna-Karin Roos, Viktor Kågström, Martin Gunnarsson, Peter Sundström, Fredrik Piehl, Susanna Brauner
Abstract
BACKGROUND AND OBJECTIVES: To describe myasthenia gravis activities of daily living (MG-ADL) in relation to clinical characteristics in a large Swedish nationwide cohort. METHODS: In a cross-sectional prevalence cohort study, the Genes and Environment in Myasthenia Gravis study, performed from November 2018 through August 2019, patients with myasthenia gravis (MG) were invited to submit an extensive 106-item life environment questionnaire, including the MG-ADL score. Patients were classified into early-onset MG (EOMG, <50 years), late-onset MG (LOMG, ≥50 years), or thymoma-associated MG (TAMG). Comparisons of disease-specific characteristics were made between subgroups, sexes, and different MG-ADL scores. RESULTS: = 0.02), but not with age at inclusion, disease subtype, or disease duration. Almost half of the population (47%) reported MG-ADL ≥3p, corresponding to an unsatisfactory symptom state. DISCUSSION: In this nationwide study, comprising more than 40% of the prevalent MG population in Sweden, almost half of the patients reported current disease symptoms associated with an unsatisfactory symptom state, indicating the need for improved treatment options.