Systemic delivery of TNF-armed myxoma virus plus immune checkpoint inhibitor eliminates lung metastatic mouse osteosarcoma
John D. Christie, Nicole Appel, Hannah Canter, Jazmin Galván Achi, Natalie Elliott, Ana Lemos de Matos, Lina S. Franco, Jacquelyn Kilbourne, Kenneth Lowe, Masmudur M. Rahman, Nancy Villa, Joshua M. Carmen, Evelyn Luna, Joseph N. Blattman, Grant McFadden
Abstract
virotherapy with TNF-α-armed MYXV represents a new potential strategy against lung metastatic cancers like osteosarcoma and can potentially act synergistically with established checkpoint immunotherapies.
Topics & Concepts
OsteosarcomaMedicineMyxoma virusTumor necrosis factor alphaCancer researchImmune systemSarcomaLungVirusImmunologyInternal medicinePathologyVirus-based gene therapy researchRNA Interference and Gene Deliveryinterferon and immune responses