Resveratrol Attenuates Ankylosing Spondylitis in Mice by Inhibiting the TLR4/NF-κB/NLRP3 Pathway and Regulating Gut Microbiota
Ming-Hui Ding, Peng-Gang Xu, Ying Wang, Bao-di Ren, Junli Zhang
Abstract
. Collectively, RES protects PG-induced AS mice by inhibiting inflammatory responses and TLR4/NF-κB/NLRP3 pathway, restoring intestinal mucosal barrier function, and regulating the composition of the gut microbiota. In other words, RES is a potential candidate for the treatment of AS.
Topics & Concepts
InflammasomeTLR4Tumor necrosis factor alphaOccludinProinflammatory cytokineBarrier functionGut floraResveratrolImmunologyBifidobacteriumInterleukinInflammationDysbiosisMicrobiologyLactobacillusMedicineBiologyPharmacologyCytokineTight junctionBiochemistryCell biologyFermentationInflammasome and immune disordersSpondyloarthritis Studies and TreatmentsAutoimmune and Inflammatory Disorders Research