Recent Developments in Heteroatom/Metal-Doped Carbon Dot-Based Image-Guided Photodynamic Therapy for Cancer
Rajkumar Sekar, Nagaraj Basavegowda, Saktishree Jena, Santhoshkumar Jayakodi, P. Elumalai, Amballa Chaitanyakumar, Prathap Somu, Kwang-Hyun Baek
Abstract
Carbon nanodots (CNDs) are advanced nanomaterials with a size of 2-10 nm and are considered zero-dimensional carbonaceous materials. CNDs have received great attention in the area of cancer theranostics. The majority of review articles have shown the improvement of CNDs for use in cancer therapy and bioimaging applications. However, there is a minimal number of consolidated studies on the currently developed doped CNDs that are used in various ways in cancer therapies. Hence, in this review, we discuss the current developments in different types of heteroatom elements/metal ion-doped CNDs along with their preparations, physicochemical and biological properties, multimodal-imaging, and emerging applications in image-guided photodynamic therapies for cancer.