Cell-based assays and molecular simulation reveal that the anti-cancer harmine is a specific matrix metalloproteinase-3 (MMP-3) inhibitor
Li‐Te Chin, Kewei Liu, Yihan Chen, Shu‐Ching Hsu, Huang Lin
Topics & Concepts
HarmineIn vivoChemistryMTT assayMatrix metalloproteinaseIC50In vitroPharmacologyCancer cellCell cultureBiochemistryMolecular biologyBiologyCancerGeneticsSynthesis and bioactivity of alkaloidsSignaling Pathways in DiseasePeptidase Inhibition and Analysis