Structure optimization, synthesis, and biological evaluation of 6-(2-amino-1H-benzo[d]imidazole-6-yl)-quinazolin-4(3H)-one derivatives as potential multi-targeted anticancer agents via Aurora A/ PI3K/BRD4 inhibition
Yanhua Fan, Fang Luo, Mingzhi Su, Qing Li, Ting Zhong, Xiong Liang, Mei Li, Meitao Yuan, Daoping Wang
Topics & Concepts
ChemistryAurora kinaseKinasePI3K/AKT/mTOR pathwayCancer researchAurora inhibitorCell cycleCell growthCancer cellCancerApoptosisBiochemistryBiologyInternal medicineMedicineProtein Degradation and InhibitorsMicrotubule and mitosis dynamicsCancer Mechanisms and Therapy