Design, synthesis, and biological evaluation of novel napabucasin-melatonin hybrids as potent STAT3 inhibitors
Chong Zhang, Limin Yang, Xiaojuan Yang, Qinghe Gao, Yan Qu, Liqiang Wu
Topics & Concepts
STAT3ChemistryApoptosisIn vivoKinasePhosphorylationIC50SH2 domainDocking (animal)STAT1BiochemistryCell biologyIn vitroBiologyProto-oncogene tyrosine-protein kinase SrcGeneticsMedicineNursingBioactive Compounds and Antitumor AgentsCytokine Signaling Pathways and InteractionsMedicinal Plant Pharmacodynamics Research