Molecular overview of progressive familial intrahepatic cholestasis
Sriram Amirneni, Nils Haep, Mohammad A Gad, Alejandro Soto–Gutiérrez, James E. Squires, Rodrigo M. Florentino
Abstract
gene, important for the trafficking of BSEP and hepatocyte membrane polarization. In this review, we provide a brief overview of the molecular mechanisms and clinical features associated with each type of PFIC based on peer reviewed journals published between 1993 and 2020.
Topics & Concepts
Progressive familial intrahepatic cholestasisCholestasisMedicineInternal medicineGastroenterologyLiver transplantationTransplantationDrug Transport and Resistance MechanismsPediatric Hepatobiliary Diseases and TreatmentsLiver Diseases and Immunity