Molecular mechanism of the anti-diabetic activity of an identified oligosaccharide from Rosa canina
SeyedShahram Miraghaee, Gholamreza Bahrami, Bahar Mohammadi, Mohammad Bahrami, Gholamreza Taheripak, Samira Keshavarzi, Atefeh Babaei, Soraya Sajadimajd, Razieh Hatami
Abstract
BACKGROUND AND PURPOSE: studies. EXPERIMENTAL APPROACH: . The effect of oligosaccharide on apoptosis and insulin secretion in cell culture media were examined. Real-time PCR was used to determine the expression level of some glucose metabolism-related regulator genes. FINDINGS / RESULTS: gene, which is related to the glucose transporter 2, was significantly reduced due to insulin concentrations. CONCLUSION AND IMPLICATIONS: was a reliable anti-diabetic agent, which acted by increasing insulin production in beta-cells of the islands of Langerhans.
Topics & Concepts
OligosaccharideApoptosisInsulinIn vitroDiabetes mellitusSalineIn vivoPharmacologyChemistryMedicineInternal medicineEndocrinologyBiologyBiochemistryBiotechnologyNatural Antidiabetic Agents StudiesBiochemical Analysis and Sensing TechniquesDiet, Metabolism, and Disease