Charting the Evolution of Chemoenzymatic Strategies in the Syntheses of Complex Natural Products
Carter N. Stout, Nour Wasfy, Fang Chen, Hans Renata
Abstract
Bolstered by recent advances in bioinformatics, genetics, and enzyme engineering, the field of chemoenzymatic synthesis has enjoyed a rapid increase in popularity and utility. This Perspective explores the integration of enzymes into multistep chemical syntheses, highlighting the unique potential of biocatalytic transformations to streamline the synthesis of complex natural products. In particular, we identify four primary conceptual approaches to chemoenzymatic synthesis and illustrate each with a number of landmark case studies. Future opportunities and challenges are also discussed.
Topics & Concepts
ChemistryPopularityPerspective (graphical)Computational biologyBiochemical engineeringNatural (archaeology)Field (mathematics)Synthetic biologyManagement scienceData scienceArtificial intelligenceComputer scienceEngineeringPsychologyBiologySocial psychologyPure mathematicsPaleontologyMathematicsMicrobial Natural Products and BiosynthesisChemical synthesis and alkaloidsEnzyme Catalysis and Immobilization