Zika Virus Infection in the Ovary Induces a Continuously Elevated Progesterone Level and Compromises Conception in Interferon Alpha/Beta Receptor-Deficient Mice
Yingying Zhang, Ziyang Sheng, Na Gao, Na Wu, Peigang Wang, Dongying Fan, Deshan Zhou, Gong Cheng, Jing An
Abstract
significantly damaged ovarian structure and function and disrupted folliculogenesis. Notably, ZIKV infection further disrupted the estrous cycle and prolonged the time to conceive in mice by causing disordered ovarian steroidogenesis. These effects were observed in both the acute phase and the recovery phase after viral elimination. Overall, the new findings provide important additions to make out the potential adverse impacts of ZIKV on reproductive health in females.
Topics & Concepts
Zika virusBiologyOvaryVirologyAntral follicleFollicular phaseInterferonViral replicationVirusThecaImmunologyInterferon type IEstrous cycleEndocrinologySexual transmissionMicrocephalyAndrologyOvarian follicleHormoneInternal medicineFlavivirusMosquito-borne diseases and controlVirology and Viral DiseasesPlant Virus Research Studies