Economic costs at age five associated with very preterm birth: multinational European cohort study
Sung Wook Kim, Lazaros Andronis, Anna‐Veera Seppänen, Adrien M. Aubert, Jennifer Zeitlin, Henrique Barros, Elizabeth S. Draper, Stavros Petrou, Belgium, Jo Lebeer, Patrick Van Reempts, Els Bruneel, Eva Cloet, Ann Oostra, Els Ortibus, Iemke Sarrechia, Denmark, Klaus Boerch, Pernille Pedersen, Estonia, Liis Toome, Heili Varendi, Mairi Männamaa, France, Pierre‐Yves Ancel, A. Burguet, P.-H. Jarreau, Véronique Pierrat, Patrick Truffert, Germany, Rolf F. Maier, Michael Zemlin, B. Misselwitz, L. Wohlers, Italy, Marina Cuttini, Ileana Croci, Virgilio Carnielli, Gina Ancora, Giacomo Faldella, Fabrizio Ferrari, The Netherlands, Arno van Heijst, Corine Koopman-Esseboom, Poland, Janusz Gadzinowski, Jan Mazela, A. Montgomery, T. Pikuła, Portugal, Henrique Barros, Raquel Costa, Carina Rodrigues, Sweden, U. Aden, United Kingdom, Elizabeth S. Draper, Alan Fenton, Samantha Johnson, EFCNI, Silke Mader, Nicole Thiele, Johanna M. Pfeil, Health Economics Team, Stavros Petrou, S. W. Kim, Lazaros Andronis, Inserm Coordination, Jennifer Zeitlin, Céline Bonnet, Rym El Rafei, Anna‐Veera Seppänen, Adrien M. Aubert
Abstract
BACKGROUND: This study aims to estimate the economic costs of care provided to children born very preterm and extremely preterm across 11 European countries, and to understand what perinatal and socioeconomic factors contribute to higher costs. METHODS: Generalised linear modelling was used to explore the association between perinatal and sociodemographic characteristics and total economic costs (€, 2016 prices) during the fifth year of life. RESULTS: Lower gestational age was associated with increased mean societal costs of €2755 (p < 0.001), €752 (p < 0.01) and €657 (p < 0.01) for children born at < 26, 26-27 and 28-29 weeks, respectively, in comparison to the reference group born at 30-31 weeks. A sensitivity analyses that excluded variables (BPD, any neonatal morbidity and presence of congenital anomaly) plausibly lying on the causal pathway between gestational age at birth and economic outcomes elevated incremental societal costs by €1482, €763 and €144 at < 26, 26-27 and 28-29 weeks, respectively, in comparison to the baseline model. CONCLUSION: This study provides new evidence about the main cost drivers associated with preterm birth in European countries. Evidence identified by this study can act as inputs within cost-effectiveness models for preventive or treatment interventions for preterm birth. IMPACT: What is the key message of your article? This study provides new evidence about the magnitude and drivers of economic costs associated with preterm birth in European countries. What does it add to the existing literature? Lower gestational age is associated with increased mean societal costs during mid-childhood with indirect costs representing a key driver of increased costs. What is the impact? For policy makers, this study adds to sparse evidence about the main cost drivers associated with preterm birth in European countries beyond the first 2 years of life.