A Comprehensive Review of Biological Roles and Interactions of Cullin-5 Protein
Iqra Bano, Anum Sumera Soomro, Syed Qamar Abbas, Amirhossein Ahmadi, Syed Shams ul Hassan, Tapan Behl, Simona Bungău
Abstract
Ubiquitination is a modification of proteins that has a powerful impact on protein function along with other cellular functions. This reaction is regulated through major enzymes, including E3 ligase as a chief enzyme. The Cullin-5 ubiquitin ligase (Cul5) possesses a variety of substrates that maintain the process of ubiquitination as well as proteasomal degradation. It regulates cell development, proliferation, and other physiological tasks in the human body. Moreover, it has been discovered that the expression of Cul5 plays a significant role in specific cancer cells while affecting the progression of tumor cells. This review is based on current knowledge about Cul5 and its expression, signaling pathways, regulation, virus-related responses, and inhibitors for therapeutic strategies.