Light-activatable photochemically targeting chimeras (PHOTACs) enable the optical control of targeted protein degradation of HDAC6
Silas Wurnig, Maria Hanl, Thomas Geiger, Shiyang Zhai, Ina Dressel, Dominika Ewa Pieńkowska, Radosław P. Nowak, Finn K. Hansen
Abstract
-state correlating with its degradation efficacy. Overall, PHOTAC 12 is a promising lead compound for the development of light-activatable HDAC6 degraders.
Topics & Concepts
Degradation (telecommunications)Cell biologyProtein degradationChemistryBiophysicsCancer researchBiologyComputer scienceTelecommunicationsProtein Degradation and InhibitorsHistone Deacetylase Inhibitors ResearchUbiquitin and proteasome pathways