Diversity-oriented synthesis of fluoroalkylated amines <i>via</i> the palladium-catalyzed divergent fluoroalkylamination of 1,3-dienes
Fu Chen, Zhaosheng Zhang, Yuzhen Li, Dongni Gao, Zi‐Ning Cui, Zhaodong Li
Abstract
the photoinduced palladium-catalyzed cross coupling of 1,3-dienes, amines and fluoroalkyl iodides, which features excellent 3,4- and 1,4-selectivity controlled by fluoroalkyl iodides, a broad substrate scope as well as good function group tolerance, and could be extended to the late-stage modification of bioactive molecules.
Topics & Concepts
PalladiumCatalysisChemistrySubstrate (aquarium)SelectivityCombinatorial chemistryMoleculeFunctional groupArylFunctional diversityOrganic chemistryPolymerAlkylBiologyEcologyGeologyOceanographyFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques