Comparative Genomics and Metabolomics in the Genus <i>Nocardia</i>
Daniel Männle, Shaun M. K. McKinnie, Shrikant Mantri, Kat Steinke, Zeyin Lu, Bradley S. Moore, Nadine Ziemert, Leonard Kaysser
Abstract
Our work emphasizes that Nocardia represent a prolific source for natural products rivaling better-characterized genera such as Streptomyces or Amycolatopsis . Furthermore, we showed that large-scale analysis of biosynthetic gene clusters using similarity networks with high stringency allows the distinction and prediction of natural product structural variations. This will facilitate future genomics-driven drug discovery campaigns.
Topics & Concepts
Natural productNocardiaGenomicsComputational biologyBiologyMetabolomicsProduct (mathematics)StreptomycesSimilarity (geometry)Drug discoveryIdentification (biology)GeneticsGeneBioinformaticsComputer scienceGenomeEcologyArtificial intelligenceBacteriaBiochemistryGeometryImage (mathematics)MathematicsActinomycetales infections and treatmentMicrobial Natural Products and BiosynthesisGenomics and Phylogenetic Studies