Targeting endosomal receptors, a new direction for polymers in nanomedicine
Paulina D. Ramírez-García, Nicholas A. Veldhuis, Nigel W. Bunnett, Thomas P. Davis
Abstract
In this perspective, we outline a new opportunity for exploiting nanoparticle delivery of antagonists to target G-protein coupled receptors localized in intracellular compartments. We discuss the specific example of antagonizing endosomal receptors involved in pain to develop long-lasting analgesics but also outline the broader application potential of this delivery approach. We discuss the materials used to target endosomal receptors and indicate the design requirements for future successful applications.
Topics & Concepts
EndosomeNanomedicineReceptorIntracellularIntracellular transportNanotechnologyPerspective (graphical)Cell biologyNeuroscienceComputational biologyComputer scienceMaterials scienceBiologyNanoparticleBiochemistryArtificial intelligenceLipid Membrane Structure and BehaviorAdvanced Drug Delivery SystemsNanoparticle-Based Drug Delivery