Soluble Nanographene C<sub>222</sub>: Synthesis and Applications for Synergistic Photodynamic/Photothermal Therapy
Xiao‐Hui Ma, Xing Gao, Jiaying Chen, Maofeng Cao, Qixuan Dai, Zhekun Jia, Yuan-Biao Zhou, Xin‐Jing Zhao, Chengchao Chu, Gang Liu, Yuan‐Zhi Tan
Abstract
Nanographene C 222, which consists of a planar graphenic plane containing 222 carbon atoms, holds the record as the largest planar nanographene synthesized to date. However, its complete insolubility makes the processing of C 222 difficult. Here we addressed this issue by introducing peripheral substituents perpendicular to the graphene plane, effectively disrupting the interlayer stacking and endowing C 222 with good solubility. We also found that the electron-withdrawing substituents played a crucial role in the cyclodehydrogenation process, converting the dendritic polyphenylene precursor to C 222 . After disrupting the interlayer stacking, the introduction of only a few peripheral carboxylic groups allowed C 222 to dissolve in phosphate buffer saline, reaching a concentration of up to 0.5 mg/mL. Taking advantage of the good photosensitizing and photothermal properties of the inner C 222 core, the resulting water-soluble C 222 emerged as a single-component agent for both photothermal and photodynamic tumor therapy, exhibiting an impressive tumor inhibition rate of 96%.