An approach to unsymmetrical 3,3′-diindolylmethanes through Pd-catalyzed cascade Heck cyclization of allenamides and <i>o</i>-ethynylanilines
Songjin Guo, Jiayi Chen, Mingjun Yi, Liuli Dong, Aijun Lin, Hequan Yao
Abstract
A highly efficient synthesis of unsymmetrical 3,3′-diindolylmethanes has been developed by palladium-catalyzed cascade Heck/cyclization reaction.
Topics & Concepts
ChemistryCascadeHeck reactionCatalysisPalladiumCombinatorial chemistryCascade reactionOrganic chemistryMedicinal chemistryChromatographySynthesis of Indole DerivativesCatalytic C–H Functionalization MethodsAxial and Atropisomeric Chirality Synthesis