LcrQ Coordinates with the YopD-LcrH Complex To Repress <i>lcrF</i> Expression and Control Type III Secretion by Yersinia pseudotuberculosis
Keke Fei, Huan Yan, Xiaoyan Zeng, Shaojia Huang, Wei Tang, Matthew S. Francis, Shiyun Chen, Yangbo Hu
Abstract
All three human-pathogenic Yesinia species, Y. pestis , Y. enterocolitica , and Y. pseudotuberculosis , employ a plasmid-encoded T3SS to target immunomodulatory effectors into host immune cells. Several plasmid-encoded regulators influence T3SS control, including the master transcriptional activator LcrF, the posttranscriptional repressor YopD, and the unassigned negative regulatory factor LcrQ.
Topics & Concepts
Yersinia pseudotuberculosisSecretionType three secretion systemYersiniaBiologyExpression (computer science)Gene expressionMicrobiologyGeneComputational biologyCell biologyGeneticsBacteriaComputer scienceVirulenceProgramming languageBiochemistryYersinia bacterium, plague, ectoparasites researchVibrio bacteria research studiesBacterial Genetics and Biotechnology