Room‐Temperature Synthesis of <i>α</i>‐Alkylated Indolin‐2‐ones via a Photo Assisted Iron Catalyzed Borrowing Hydrogen Reaction
Dingguo Song, Rong Chen, Weiwei Huang, Pengtao Yang, Lingxin Chen, Jialin Zhang, Fei Ling, Fei Ling, Weihui Zhong
Abstract
Abstract We reported a visible‐light‐induced iron‐catalyzed α ‐alkylation of oxindoles with alcohols to offer a variety of α ‐alkyled oxindoles at room temperature. This reaction featured broad substrate scope with good functional tolerance under simple conditions. Through a series of controlled experiments, we tried to elucidated the important role of light in this borrowing hydrogen (BH) reaction.
Topics & Concepts
ChemistryAlkylationCatalysisHydrogenCombinatorial chemistryOrganic chemistryPhotochemistryAsymmetric Hydrogenation and CatalysisSynthesis of Indole DerivativesChemical Synthesis and Analysis