Single-Cell Analyses Identify Dysfunctional CD16+ CD8 T Cells in Smokers
Suzanne N. Martos, Michelle R. Campbell, Oswaldo A. Lozoya, Xuting Wang, Brian D. Bennett, Isabel J. B. Thompson, Ma Wan, Gary S. Pittman, Douglas A. Bell
Abstract
) cells. Indicative of immune aging, smokers' CD8 T cells are biased toward differentiated cells and smokers have fewer naïve cells than nonsmokers. DNA methylation-based models show that smoking dose is associated with accelerated aging and decreased telomere length, a biomarker of T cell senescence. Immune aging accompanies T cell senescence, which can ultimately lead to impaired immune function. This suggests a role for smoking-induced, senescence-associated immune dysregulation in smoking-mediated pathologies.
Topics & Concepts
Dysfunctional familyCD16Cytotoxic T cellCD8MedicineImmunologyBiologyGeneticsAntigenCD3Clinical psychologyIn vitroImmune Cell Function and InteractionT-cell and B-cell ImmunologyImmunotherapy and Immune Responses