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Exosomal SLC1A5 from senescent endothelial cells promotes gastric cancer progression by dampening ferroptosis via the EGFR/SRC/YAP1/GPX4 signaling

Yan Zhang, Yuanyuan Ren, Zhen Wang, Xi Zhang, Xiaofang Li, Y. Yu, Qian Lu, Yuyan Xiong

2025Free Radical Biology and Medicine9 citationsDOI

Topics & Concepts

YAP1Proto-oncogene tyrosine-protein kinase SrcCancer researchAutophagyChemistryCell biologyCancerSignal transductionMedicineBiologyApoptosisInternal medicineBiochemistryGeneTranscription factorCancer-related molecular mechanisms researchHippo pathway signaling and YAP/TAZFerroptosis and cancer prognosis
Exosomal SLC1A5 from senescent endothelial cells promotes gastric cancer progression by dampening ferroptosis via the EGFR/SRC/YAP1/GPX4 signaling | Litcius