MAP4K4 negatively regulates CD8 T cell–mediated antitumor and antiviral immunity
Emel Esen, Ismail Sergin, Rajiv Jesudason, Patricia Himmels, Joshua D. Webster, Hua Zhang, Min Xu, Robert Piskol, Erin McNamara, Stephen E. Gould, Aude-Hélène Capietto, Lélia Delamarre, Kevin B. Walsh, Weilan Ye
Abstract
in adult animals is tolerated under homeostatic conditions. Our results uncover MAP4K4 as a potential target to augment antitumor and antiviral immunity.
Topics & Concepts
CD8ImmunityCytotoxic T cellCancer researchImmunologyBiologyCell mediated immunityCellT cellImmune systemIn vitroBiochemistryCAR-T cell therapy researchMelanoma and MAPK PathwaysPeptidase Inhibition and Analysis