Mitochondrial outer membrane protein MTUS1/ATIP1 exerts antitumor effects through ROS-induced mitochondrial pyroptosis in head and neck squamous cell carcinoma
Dongxiao Tang, Luodan Zhao, Shuojin Huang, Wuguo Li, Qianting He, Anxun Wang
Abstract
. MTUS1/ATIP1 localized in the outer mitochondrial membrane, influence the morphology, movement and metabolism of mitochondria and stimulated oxidative stress in HNSCC cells by directly interacting with MFN2. MTUS1/ATIP1 activated ROS, recruiting Bax to mitochondria, facilitating cytochrome c release to the cytosol to activate caspase-3, and inducing GSDME-dependent pyroptotic death in HNSCC cells. Our findings showed that MTUS1/ATIP1 localized in the outer mitochondrial membrane in HNSCC cells and mediated anticancer effects through ROS-induced pyroptosis, which may provide a novel therapeutic strategy for HNSCC treatment.
Topics & Concepts
PyroptosisHead and neck squamous-cell carcinomaMitochondrionBasal cellApoptosisChemistryCell biologyInner mitochondrial membraneCancer researchBiologyMolecular biologyProgrammed cell deathPathologyMedicineBiochemistryHead and neck cancerCancerGeneticsInflammasome and immune disordersRNA modifications and cancerinterferon and immune responses