Iridium-Catalyzed Enantioselective α-C(sp<sup>3</sup>)–H Borylation of Azacycles
Lili Chen, Yuhuan Yang, Luhua Liu, Qian Gao, Senmiao Xu
Abstract
)-H borylation of a wide range of azacycles. The combination of an iridium precursor and a chiral bidentate boryl ligand has been shown to effectively differentiate enantiotropic methylene C-H bonds from a single carbon center, affording a variety of synthetically useful azacycles from readily available starting materials with good to excellent enantioselectivities.
Topics & Concepts
BorylationChemistryEnantioselective synthesisIridiumDenticityCatalysisLigand (biochemistry)MethyleneCombinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryCrystal structureArylAlkylReceptorBiochemistryCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisOrganoboron and organosilicon chemistry