Enantioselective Intermolecular Heck and Reductive Heck Reactions of Aryl Triflates, Mesylates, and Tosylates Catalyzed by Nickel
Xiaolei Huang, Shenghan Teng, Yonggui Robin, Wenqiang Xu, Maoping Pu, Yun‐Dong Wu, Jianrong Steve Zhou
Abstract
Nickel-catalyzed intermolecular Heck reaction of cycloalkenes proceeds well with aryl triflates, mesylates and tosylates in excellent enantiomeric ratios. The asymmetric reductive Heck reaction also works with a 2-cyclopentenone ketal, which is equivalent to conjugate arylation of the enone itself.
Topics & Concepts
NickelArylEnantioselective synthesisHeck reactionIntermolecular forceCatalysisChemistryOrganic chemistryMedicinal chemistryPalladiumMoleculeAlkylCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms