Selective photoredox decarboxylation of α-ketoacids to allylic ketones and 1,4-dicarbonyl compounds dependent on cobaloxime catalysis
Hong Zhang, Qian Xiao, Xu-Kuan Qi, Xue‐Wang Gao, Qing‐Xiao Tong, Jian‐Ji Zhong
Abstract
A photoredox/cobaloxime co-catalyzed coupling reaction of α-ketoacids and methacrylates to obtain allylic ketones is described. Without the cobaloxime catalyst, 1,4-dicarbonyl compounds are generated. The cobaloxime catalyst enables dehydrogenation to generate the formation of new olefins. The generality, good substrate scope and mild conditions are good features in the photoredox/cobaloxime catalysis protocol, and this method will provide new opportunities for the functionalization of more olefins.
Topics & Concepts
DecarboxylationAllylic rearrangementChemistryCatalysisMedicinal chemistryOrganic chemistryRadical Photochemical ReactionsCO2 Reduction Techniques and CatalystsFluorine in Organic Chemistry