Combined cancer immunotherapy with lipid nanoparticle delivery of oligo-based cGAS-agonistic adjuvant and peptide or mRNA vaccines
Shurong Zhou, Yuqing Liang, Yu Hao, Qiyan Wang, You Xu, Ting Su, Furong Cheng, Guizhi Zhu
Abstract
T cell responses in mice. The combination of LNP-delivered Svg3 with peptide or mRNA encoding antigens promotes anti-tumor responses, reduces immune suppression, and enhances tumor therapeutic efficacy when combined with ICB.
Topics & Concepts
Agonistic behaviourCancer immunotherapyAdjuvantOligonucleotideImmunotherapyMessenger RNACancerPeptideCancer researchVirologyMedicineBiologyImmunologyGeneInternal medicineBiochemistryPsychiatryAggressionImmunotherapy and Immune ResponsesCancer Immunotherapy and BiomarkersRNA Interference and Gene Delivery