<i>Lactiplantibacillus plantarum</i> HEAL9 attenuates cognitive impairment and progression of Alzheimer's disease and related bowel symptoms in SAMP8 mice by modulating microbiota-gut-inflammasome-brain axis
Clelia Di Salvo, Vanessa D’Antongiovanni, Laura Benvenuti, Antonio d’Amati, Chiara Ippolito, Cristina Segnani, Christophe Pierucci, Gabriele Bellini, Tiziana Annese, Daniela Virgintino, Rocchina Colucci, Luca Antonioli, Matteo Fornai, Mariella Errede, Nunzia Bernardini, Carolina Pellegrini
Abstract
the modulation of microbiota-gut-inflammasome-brain signalling. Thus, dietary supplementation with HEAL9 could be considered as a suitable therapeutical option for the treatment of AD and related intestinal symptoms in the early stages of the disease.
Topics & Concepts
InflammasomeGut–brain axisGut floraMedicineDiseaseCognitionCognitive impairmentCognitive declineInflammatory bowel diseaseImmunologyMotilityNeuroscienceInternal medicineInflammationPsychologyBiologyDementiaPsychiatryGeneticsGut microbiota and healthTryptophan and brain disordersGastrointestinal motility and disorders