The glucose sensor NSUN2-m<sup>5</sup>C modification regulates tumor-immune glucose metabolism reprogramming to drive hepatocellular carcinoma evolution
Jing He, Boqiang Liu, Weijun Zhao, Hao Shen, Junqing Wang, Weiqi Li, Chenqi Jin, Yifan Wang, Xiujun Cai, Liang Shi
Abstract
T cell dysfunction. Building on these insights, we designed a dual-targeting strategy combining GLUT1/NSUN2 axis inhibitor WZB117 with PD-L1 blockade, which synergistically suppressed tumor evolution and reversed immunosuppression in preclinical models, suggesting a novel synergistic therapeutic strategy for treatment-resistant HCC.
Topics & Concepts
Hepatocellular carcinomaReprogrammingMetabolismImmune systemCarbohydrate metabolismChemistryCancer researchBiologyBiochemistryImmunologyGeneCancer, Hypoxia, and MetabolismPancreatic function and diabetesRNA modifications and cancer