Discovery of a Novel Non-Narcotic Analgesic Derived from the CL-20 Explosive: Synthesis, Pharmacology, and Target Identification of Thiowurtzine, a Potent Inhibitor of the Opioid Receptors and the Ion Channels
Stephanie Aguero, Simon Mégy, V. V. Eremina, А. И. Калашников, С. Г. Крылова, D. A. Kulagina, К. А. Лопатина, Mailys Fournier, T. N. Povetyeva, Alexander Vorozhtsov, S. V. Sysolyatin, В. В. Жданов, Raphaël Terreux
Abstract
voltage-gated calcium channel.
Topics & Concepts
AnalgesicPharmacologyMolecular PharmacologyIon channelChemistryMechanism of actionIn vivoOpioidReceptorNarcoticDrugDocking (animal)Drug discoveryMedicineIn vitroBiochemistryBiologyAnesthesiaNursingBiotechnologyComputational Drug Discovery MethodsPharmacological Receptor Mechanisms and EffectsCholinesterase and Neurodegenerative Diseases