Litcius/Paper detail

Discovery of a Novel Non-Narcotic Analgesic Derived from the CL-20 Explosive: Synthesis, Pharmacology, and Target Identification of Thiowurtzine, a Potent Inhibitor of the Opioid Receptors and the Ion Channels

Stephanie Aguero, Simon Mégy, V. V. Eremina, А. И. Калашников, С. Г. Крылова, D. A. Kulagina, К. А. Лопатина, Mailys Fournier, T. N. Povetyeva, Alexander Vorozhtsov, S. V. Sysolyatin, В. В. Жданов, Raphaël Terreux

2021ACS Omega24 citationsDOIOpen Access PDF

Abstract

voltage-gated calcium channel.

Topics & Concepts

AnalgesicPharmacologyMolecular PharmacologyIon channelChemistryMechanism of actionIn vivoOpioidReceptorNarcoticDrugDocking (animal)Drug discoveryMedicineIn vitroBiochemistryBiologyAnesthesiaNursingBiotechnologyComputational Drug Discovery MethodsPharmacological Receptor Mechanisms and EffectsCholinesterase and Neurodegenerative Diseases