N<sup>7</sup>-methylguanosine (m<sup>7</sup>G) tRNA modification: a novel autophagy modulator in cancer
Hui Han, Siyi Zheng, Shuibin Lin
Abstract
G modification, link translational machinery with autophagic machinery, and suggest that METTL1 and its downstream signaling axis could be potential therapeutic targets for ESCC treatment.
Topics & Concepts
AutophagyBiologyCarcinogenesismTORC1Translation (biology)EpigeneticsPI3K/AKT/mTOR pathwayCell biologyCancer researchTransfer RNARNACancerSignal transductionMessenger RNAGeneticsGeneApoptosisRNA modifications and cancerCancer-related gene regulationAutophagy in Disease and Therapy