Chitosan oligosaccharides exert neuroprotective effects<i>via</i>modulating the PI3K/Akt/Bcl-2 pathway in a Parkinsonian model
Bin Wang, Ling Wang, Yufei Qu, Jingyu Lu, Wenshui Xia
Abstract
reducing the overexpression of α-synuclein, alleviating neuroinflammation, and activating the PI3K/Akt/Bcl-2 pathway to reduce apoptosis. COS3 exhibited a better effect on protecting dopaminergic neurons; however, COS2 provided a better effect on reducing the overexpression of α-synuclein. To conclude, the neuroprotective activity makes COSs a viable candidate as an ingredient for healthcare products.
Topics & Concepts
MPTPNeuroprotectionDopaminergicPI3K/AKT/mTOR pathwayPharmacologyProtein kinase BChemistryNeuroinflammationParkinson's diseaseSignal transductionMedicineBiochemistryDopamineDiseaseInternal medicineNanocomposite Films for Food PackagingStudies on Chitinases and ChitosanasesParkinson's Disease Mechanisms and Treatments