Discovery of sulfonyl hydrazone derivative as a new selective PDE4A and PDE4D inhibitor by lead-optimization approach on the prototype LASSBio-448: In vitro and in vivo preclinical studies
Isabelle Karine da Costa Nunes, Éverton Tenório de Souza, Italo Rossi Roseno Martins, Gisele Barbosa, Manoel Oliveira de Moraes, Millena de Melo Medeiros, Sheyla Welma Duarte Silva, Tatiane Luciano Balliano, Bagnólia Araújo da Silva, Patrı́cia Silva, Vinícius F. Carvalho, Marco A. Martins, Lı́dia Moreira Lima
Topics & Concepts
ChemistrySulfonamideSulfonylIn vivoPharmacologyStereochemistryAlkylBiologyOrganic chemistryBiotechnologyMedicinePhosphodiesterase function and regulationMast cells and histaminePhenothiazines and Benzothiazines Synthesis and Activities