Prolonged near-infrared fluorescence imaging of microRNAs and proteases <i>in vivo</i> by aggregation-enhanced emission from DNA-AuNC nanomachines
Ting Wang, Kai Jiang, Yifan Wang, Limei Xu, Yingqi Liu, Shiling Zhang, Weiwei Xiong, Yemei Wang, Fenfen Zheng, Jun‐Jie Zhu
Abstract
We have designed a deoxyribonucleic acid-gold nanocluster (DNA-AuNC) nanomachine for long-term imaging of mRNA and protease, harnessing the toehold-mediated stand displacement (TMSD) reaction-driven aggregation-induced enhanced emission of AuNCs.
Topics & Concepts
ProteasesIn vivoFluorescencemicroRNADNAAggregation-induced emissionBiophysicsChemistryInfraredCell biologyNanotechnologyMaterials scienceBiologyBiochemistryOpticsGeneticsPhysicsGeneEnzymeAdvanced biosensing and bioanalysis techniquesNanocluster Synthesis and ApplicationsGold and Silver Nanoparticles Synthesis and Applications