Revolution of vitamin E production by starting from microbial fermented farnesene to isophytol
Ziling Ye, Bin Shi, Yanglei Huang, Tian Ma, Zilei Xiang, Ben Hu, Zhaolin Kuang, Man Huang, Xiaoying Lin, Tian Zhu, Zixin Deng, Kun Shen, Tiangang Liu
Abstract
was achieved (55.4 g/L). This farnesene can be chemically converted into isophytol in three steps with approximately 92% yield, which is economically equal to that from the best total chemical synthesis. Furthermore, we co-produced lycopene and farnesene to reduce the cost of farnesene. A factory based on this new process was successfully operated in Hubei Province, China, in 2017, with an annual output of 30,000 tons of vitamin E. This new process has completely changed the vitamin E market due to its low cost and safety.
Topics & Concepts
Metabolic engineeringFermentationChemistryVitaminYield (engineering)Food scienceEngineeringBiochemistryEnzymeMetallurgyMaterials sciencePlant biochemistry and biosynthesisPhotosynthetic Processes and MechanismsAntioxidant Activity and Oxidative Stress