Design, synthesis, and biological evaluation of pyrido[2,3-d]pyrimidin-7(8H)-one derivatives as potent USP1 inhibitors
Hongrui Li, Ben-Jin Liu, Jiahao Xu, Shanshan Song, Ruixian Ba, Junjie Zhang, Xia‐Juan Huan, Dun Wang, Ze‐Hong Miao, Tongchao Liu, Jin‐Xue He, Bing Xiong, Bing Xiong
Topics & Concepts
OlaparibChemistryFlow cytometryPARP inhibitorPharmacologyStereochemistryCombinatorial chemistryPoly ADP ribose polymeraseBiochemistryEnzymeMolecular biologyPolymeraseBiologyMedicinePARP inhibition in cancer therapyUbiquitin and proteasome pathwaysCell death mechanisms and regulation