Deletion of Small GTPase H-Ras Rescues Memory Deficits and Reduces Amyloid Plaque-Associated Dendritic Spine Loss in Transgenic Alzheimer’s Mice
Wenhui Qu, Angela Jeong, Rui Zhong, Josslen S. Thieschafer, Andrea Gram, Ling Li
Topics & Concepts
HRASGTPaseSmall GTPaseBiologyCell biologyGenetically modified mouseNeuroinflammationDendritic spineRap1Amyloid precursor proteinPresenilinAstrogliosisAlzheimer's diseaseTransgeneSignal transductionNeuroscienceCancer researchImmunologyMedicinePathologyInflammationBiochemistryMutationDiseaseCentral nervous systemKRASGeneHippocampal formationAlzheimer's disease research and treatmentsNeuroscience and Neuropharmacology ResearchTrace Elements in Health