Targeting hypoxia-inducible factor-1, for cancer treatment: Recent advances in developing small-molecule inhibitors from natural compounds
Zhaowu Ma, Xiaoqiang Xiang, Shiya Li, Peng Xie, Quan Gong, Boon-Cher Goh, Lingzhi Wang
Topics & Concepts
HIF1ACancerDrug discoveryCarcinogenesisTranscription factorMetastasisDiseaseBiologyBioinformaticsComputational biologyCancer researchHypoxia (environmental)AngiogenesisMedicineChemistryGeneInternal medicineGeneticsOrganic chemistryOxygenCancer, Hypoxia, and MetabolismCancer-related Molecular PathwaysUbiquitin and proteasome pathways